San Francisco 49ers receiver Mario Manningham is not listed on the team’s injury report. Thus, he is likely in line to make his season debut Sunday against Carolina.
It appears Aldon Smith will play as well against the Carolina Panthers.
It will be the first game Smith, a premier pass-rusher, is back with San Francisco after he spent five weeks in a treatment center.
This should provide a huge boost for the Niners team.

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